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  1. Yong, Y. N., Dong, J., Pakkiri, L. S., Henry, C. J., Haldar, S., & Drum, C. L. (2023). Chronometabolism: The Timing of the Consumption of Meals Has a Greater Influence Than Glycemic Index (GI) on the Postprandial Metabolome. Metabolites13(4), 490.[Link]
  2. Ng, M. L., Ang, X., Yap, K. Y., Ng, J. J., Goh, E. C. H., Khoo, B. B. J., … & Drum, C. L. (2023). Novel Oxidative Stress Biomarkers with Risk Prognosis Values in Heart Failure. Biomedicines11(3), 917.[Link]


  1. Tay, S. H., Santosa, A., Goh, E. C. H., Xu, C. X., Wu, L. H., Bigliardi-Qi, M., … & Bigliardi, P. L. (2022). Distinct transcriptomic and metabolomic profiles characterize NSAID-induced urticaria/angioedema patients undergoing aspirin desensitization. Journal of Allergy and Clinical Immunology150(6), 1486-1497.[Linke]
  2. Sadeghi, S., Vallerinteavide Mavelli, G., Vaidya, S. S., & Drum, C. L. (2022). Gastrointestinal Tract Stabilized Protein Delivery Using Disulfide Thermostable Exoshell System. International Journal of Molecular Sciences23(17), 9856.[Link]
  3. Sadeghi, S., Masurkar, N. D., Vallerinteavide Mavelli, G., Deshpande, S., Kok Yong Tan, W., Yee, S., … & Drum, C. L. (2022). Bioorthogonal Catalysis for Treatment of Solid Tumors Using Thermostable, Self-Assembling, Single Enzyme Nanoparticles and Natural Product Conversion with Indole-3-acetic Acid. ACS nano16(7), 10292-10301.[Link]
  4. Ng, M. L., Kuan, W. S., Pakkiri, L. S., Goh, E. C. H., Wu, L. H., & Drum, C. L. (2022). Deep phenotyping of oxidative stress in emergency room patients reveals homoarginine as a novel predictor of sepsis severity, length of hospital stay, and length of intensive care unit stay. Frontiers in Medicine9.[Link]


  1. Vallerinteavide Mavelli, G., Sadeghi, S., Vaidya, S. S., Kong, S. N., & Drum, C. L. (2021). Nanoencapsulation as a General Solution for Lyophilization of Labile Substrates. Pharmaceutics13(11), 1790.[Link]
  2. Sadeghi, S., Deshpande, S., Vallerinteavide Mavelli, G., Aksoyoglu, A., Bafna, J., Winterhalter, M., … & Drum, C. L. (2021). A general approach to protein folding using thermostable exoshells. Nature Communications12(1), 5720.[Link]
  3. Dear, J. W., Ng, M. L., Bateman, D. N., Leroy Sivappiragasam, P., Choi, H., Khoo, B. B. J., … & Drum, C. L. (2021). A metabolomic analysis of thiol response for standard and modified N‐acetyl cysteine treatment regimens in patients with acetaminophen overdose. Clinical and Translational Science14(4), 1476-1489.[Link]
  4. Widjaja, A. A., Dong, J., Adami, E., Viswanathan, S., Ng, B., Pakkiri, L. S., … & Cook, S. A. (2021). Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury. Science Translational Medicine13(597), eaba8146.[Link]
  5. Deshpande, S., Sadeghi, S., Vallerinteavide, G. M., Aksoyoglu, M. A., Bafna, J., Kini, M., … & Drum, C. (2021). Laboratory scale production of complex protein substrates using substrate-complimentary nanoenvironments.[Link]
  6. Gao, J., Low, K. H. J., Chen, Y., Tai, E. S., Chung, T. S., & Drum, C. L. (2021). High recovery, point‐of‐collection plasma separation from blood using electrospun polyacrylonitrile membranes. AIChE Journal67(2), e17088.[Link]


  1. Sadeghi, S., Lee, W. K., Kong, S. N., Shetty, A., & Drum, C. L. (2020). Oral administration of protein nanoparticles: An emerging route to disease treatment. Pharmacological Research158, 104685.[Link]
  2. Yip, C., Seneviratna, A., Tan, S. H., Khaing, T., Chan, S. P., Loh, J., … & Chan, M. Y. (2020). Patients with acute and chronic coronary syndromes have elevated long-term thrombin generation. Journal of Thrombosis and Thrombolysis50, 421-429.[Link]
  3. Landreh, M., Sahin, C., Gault, J., Sadeghi, S., Drum, C. L., Uzdavinys, P., … & Marklund, E. G. (2020). Predicting the shapes of protein complexes through collision cross section measurements and database searches. Analytical Chemistry92(18), 12297-12303.[Link]
  4. Yee, W. L. S., & Drum, C. L. (2020). Increasing Complexity to Simplify Clinical Care: High Resolution Mass Spectrometry as an Enabler of AI Guided Clinical and Therapeutic Monitoring. Advanced Therapeutics3(4), 1900163.[Link]
  5. Tai, Y. K., Ng, C., Purnamawati, K., Lye Yee Yap, J., Yin, J. N., Wong, C., … & Franco-Obregón, A. (2020). Magnetic fields modulate metabolism and gut microbiome in correlation withPgc-1 alpha expression: Follow-up to an in vitro magnetic mitohormetic study. The FASEB Journal34(8), 11143-11167.[Link]


  1. Chan, M. Y., Efthymios, M., Tan, S. H., Johnson, M. A., See, K., Pickering, J., … & Richards, A. M. (2019). Prioritization of Post-Myocardial Infarction Heart Failure Targets Using Large-Scale Plasma Proteomics and Genome-Wide Single-Cardiac Cell Transcriptomics. Circulation140(Suppl_1), A13282-A13282.[Link]
  2. Gao, J., Low, K. H. J., Drum, C. L., Tai, E. S., & Chung, T. S. (2019, November). Membrane Developments for Decellularization of Blood Via Gravity in Dry Plasma Spot Applications. In 2019 AIChE Annual Meeting. AIChE.[Link]
  3. Gao, J., Low, K. H. J., Drum, C. L., Tai, E. S., & Chung, T. S. (2019, November). Keynote: Separation of Blood Cells from Plasma through Membranes in Dry Plasma Spot Applications. In 2019 AIChE Annual Meeting. AIChE.[Link]
  4. Widjaja, A. A., Dong, J., Adami, E., Viswanathan, S., Ng, B., Singh, B. K., … & Cook, S. A. (2019). Redefining Interleukin 11 as a regeneration-limiting hepatotoxin. bioRxiv, 830018.[Link]
  5. Krishnamurthy, S., Muthukumaran, P., Jayakumar, M. K. G., Lisse, D., Masurkar, N. D., Xu, C., … & Drum, C. L. (2019). Surface protein engineering increases the circulation time of a cell membrane-based nanotherapeutic. Nanomedicine: Nanotechnology, Biology and Medicine18, 169-178.[Link]
  6. Haldar, S., Pakkiri, L. S., Lim, J., Chia, S. C., Ponnalagu, S., Drum, C. L., & Henry, C. J. (2019). Reductions in postprandial plasma allantoin concentrations with increasing doses of polyphenol rich curry intake–a randomized crossover trial. Frontiers in Physiology9, 1899.[Link]


  1. Purnamawati, K., Ong, J. A. H., Deshpande, S., Tan, W. K. Y., Masurkar, N., Low, J. K., & Drum, C. L. (2018). The importance of sex stratification in autoimmune disease biomarker research: a systematic review. Frontiers in immunology9, 1208.[Link]
  2. Tan, W. K., Purnamawati, K., Pakkiri, L. S., Tan, S. H., Yang, X., Chan, M. Y., & Drum, C. L. (2018). Sources of variability in quantifying circulating thymosin beta-4: literature review and recommendations. Expert Opinion on Biological Therapy18(sup1), 141-147.[Link]
  3. Drum, Chester Lee, et al. “Compositions and methods for protein expression and delivery.”[Link]


  1. Patra, A., Ding, T., Hong, M., Richards, A. M., Wong, T. I., Zhou, X., Drum, C. L. Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum. J. Vis. Exp. (130), e55597, doi:10.3791/55597 (2017).[Link]
  2. Drum C L. Light-Activated Two-Component Protein Binding Matrix: U.S. Patent Application 15/521,048[P]. 2017-12-7.[Link]
  3. Deshpande S, Masurkar N, Mavelli GV, Desai M, Chakraborty G, Chan JM and Drum CL. Thermostable exoshells fold and stabilize recombinant proteins. Nature Communications (2017) [Link]
  4. Ohlson S, Kaur J, Raida M, Niss U, Bengala T, Drum CL, et al. Direct Analysis − No Sample Preparation − of Bioavailable Cortisol in Human Plasma by Weak Affinity Chromatography (WAC). Journal of Chromatography B. 2017 Jul. (IF = 4.17) [Link]
  5. Drum CL, Tan KY, Chan SP, Pakkiri LS, Chong PC, Liew OW, et. al, Thymosin beta-4 is elevated in women with heart failure with preserved ejection fraction, Journal of the American Heart Association. American Heart Association, Inc; 2017 Jun 1;6(6):e005586. (IF = 5.12) [Link]
  6. Patra A, Ding T, Drum CL, Using extraordinary optical transmission to quantify cardiac biomarkers in human serum, JoVE (in press)


  1. Patra A, Ding T, Engudar G, Yi W, Dykas M, Liedberg B, Kah J, Venkatesan T, Drum CL. Component Specific Analysis of Plasma Protein Corona Formation On Gold Nanoparticles Using Multiplexed Surface Plasmon Resonance. Small. 2016 03-20;12(9):1174-82. doi: 10.1002/smll.201501603. (5yr IF = 8.32) [Link]
  2. Garcia-Miralles M, Ooi J, Bardile CF, Tan LJ, George M, Drum CL, et al. Treatment with the MAO-A inhibitor clorgyline elevates monoamine neurotransmitter levels and improves affective phenotypes in a mouse model of Huntington disease. Experimental Neurology. 2016 Jan 26;278:4–10. (5yr IF = 4.479, 2yr IF = 4.657) [Link]
  3. Halliwell B, Cheah IK, Drum CL. Ergothioneine, an adaptive antioxidant for the protection of injured tissues? A hypothesis. Biochem Biophys Res Commun. 2016 Jan 6. doi: 10.1016/j.bbrc.2015.12.124 (5yr IF = 2.392, 2yr IF = 2.371) [Link]


  1. Ding T, Hong M, Richards AM, It Wong Ten, Zhou X, Drum CL. Quantification of a Cardiac Biomarker in Human Serum Using Extraordinary Optical Transmission (EOT). PLoS ONE. 2015 Mar 16;10(3):e0120974. (IF = 3.02) [Link]
  2. Drum CL. System-level prescriptions for adaptive drug licensing. Science Translational Medicine. 2015 Mar 4;7(277):277ec36. [Link]
  3. Chan JM, Wong KHK, Richards AM, Drum CL. Microengineering in cardiovascular research: new developments and translational applications. Cardiovascular Research. 2015 Feb 17. (IF = 5.46) (editor’s choice) [Link]
  4. Drum CL. TRIPOD puts prediction models on a firmer footing. Science Translational Medicine. 2015 Jan 28;7(272):272ec14–4. [Link]
  5. Drum CL. Watch your leftovers: Remnant cholesterol brings oversized risk to cardiovascular health. Science Translational Medicine. 2014 Dec 3;6(265):205. [Link]


  1. Drum CL. Short circuiting mitochondria leads to improvement in mouse models of diabetes. Science Translational Medicine. 2014 Oct 22;6(259):179. [Link]
  2. Drum CL. The ubiquitinase pathway takes center stage in viral myocarditis. Science Translational Medicine. 2014 Sep 10;6(253):155. [Link]
  3. Yu J, Tao D, Ng EX, Drum CL, Liu AQ, Chen C-H. Real-time measurement of thrombin generation using continuous droplet microfluidics. Biomicrofluidics. 2014 Sep;8(5):052108. [Link]
  4. Drum CL. Long non-coding RNAs in myocardial infarction. Science Translational Medicine. 2014 Jul 30;6(247):131. [Link]
  5. Drum CL. Taking Cancer Cells Out of Circulation. Science Translational Medicine. 2014 Jun 18;6(241):104. [Link]
  6. Drum CL. Magnetic Resonance: It’s a Gas! Science Translational Medicine. 2014 May 7;6(235):80. [Link]
  7. Drum CL. Getting to the Heart of Consciousness. Science Translational Medicine. 2014 Mar 26;6(229):53. [Link]


  1. Eichler H-G, Oye K, Baird LG, Abadie E, Brown J, Drum CL, et al. Adaptive licensing: taking the next step in the evolution of drug approval. Clin Pharmacol Ther. 2012 Mar;91(3):426–37. [Link]
  2. De Sousa FB, Lima AC, Denadai AML, Anconi CPA, De Almeida WB, Novato WTG, et al. Superstructure based on β-CD self-assembly induced by a small guest molecule. Phys Chem Chem Phys. The Royal Society of Chemistry; 2012 Feb 14;14(6):1934–44. [Link]


  1. Chan JM, Rhee J-W, Drum CL, Bronson RT, Golomb G, Langer R, et al. In vivo prevention of arterial restenosis with paclitaxel-encapsulated targeted lipid-polymeric nanoparticles. Proc Natl Acad Sci USA. National Acad Sciences; 2011 Nov 29;108(48):19347–52. [Link]


  1. Shen Y, Guo Q, Zhukovskaya NL, Drum CL, Bohm A, Tang W-J. Structure of anthrax edema factor-calmodulin-adenosine 5′-(alpha,beta-methylene)-triphosphate complex reveals an alternative mode of ATP binding to the catalytic site. Biochem Biophys Res Commun. 2004 Apr 30;317(2):309–14. [Link]


  1. Drum CL, Yan S-Z, Bard J, Shen Y-Q, Lu D, Soelaiman S, et al. Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin. Nature. 2002 Jan 24;415(6870):396–402. [Link]


  1. Drum CL, Shen Y, Rice PA, Bohm A, Tang WJ. Crystallization and preliminary X-ray study of the edema factor exotoxin adenylyl cyclase domain from Bacillus anthracis in the presence of its activator, calmodulin. Acta Crystallogr D Biol Crystallogr. 2001 Dec;57(Pt 12):1881–4. [Link]

1995 – 2000

  1. Drum CL, Yan SZ, Sarac R, Mabuchi Y, Beckingham K, Bohm A, et al. An extended conformation of calmodulin induces interactions between the structural domains of adenylyl cyclase from Bacillus anthracis to promote catalysis. J Biol Chem. American Society for Biochemistry and Molecular Biology; 2000 Nov 17;275(46):36334–40. [Link]
  2. Tang WJ, Yan S, Drum CL. Class III adenylyl cyclases: regulation and underlying mechanisms. Adv Second Messenger Phosphoprotein Res. 1998;32:137–51. [Link]
  3. Benzinger GR, Drum CL, Chen LQ, Kallen RG, Hanck DA, Hanck D. Differences in the binding sites of two site-3 sodium channel toxins. Pflugers Arch. 1997 Nov;434(6):742–9. [Link]
  4. Kelso GJ, Drum CL, Hanck DA, Blumenthal KM. Role for Pro-13 in directing high-affinity binding of anthopleurin B to the voltage-sensitive sodium channel. Biochemistry. 1996 Nov 12;35(45):14157–64. [Link]
  5. Dias-Kadambi BL, Combs KA, Drum CL, Hanck DA, Blumenthal KM. The role of exposed tryptophan residues in the activity of the cardiotonic polypeptide anthopleurin B. J Biol Chem. 1996 Sep 27;271(39):23828–35. [Link]
  6. Dias-Kadambi BL, Drum CL, Hanck DA, Blumenthal KM. Leucine 18, a hydrophobic residue essential for high affinity binding of anthopleurin B to the voltage-sensitive sodium channel. J Biol Chem. 1996 Apr 19;271(16):9422–8. [Link]
  7. Khera PK, Benzinger GR, Lipkind G, Drum CL, Hanck DA, Blumenthal KM. Multiple cationic residues of anthopleurin B that determine high affinity and channel isoform discrimination. Biochemistry. 1995 Jul 11;34(27):8533–41. [Link]